Common Manifestations
Presentation varies with disease stage, duration, comorbidity burden, and the organ system involved. Some features are intermittent and nonspecific, whereas others point more strongly toward inflammation, structural injury, endocrine disturbance, neurovascular change, or progressive loss of function.
- Fatigue or weakness
- Weight gain or weight loss
- Heat or cold intolerance
- Polyuria or polydipsia
- Menstrual or fertility change
- Mood, skin, or hair change